SR4 [Sat Jan 21 2017 11:25:47 GMT+0100 (CET)]

antitoxin RNA, inhibits bsrG translation and causes destabilization of the bsrG mRNA

locus: new_2273724_2273988_c

pI: 0.00

mw: 0.00 kDa

function: protection of the cell

product: antitoxin RNA

synonyms: SR4,S810

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems]
• [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.5|Regulatory RNAs]

[SW|Categories] containing this gene/protein

• [SW|toxins, antitoxins and immunity against toxins], [SW|SP-beta prophage], [SW|ncRNA]

Gene

Coordinates on the chromosome: 2,273,724 -> 2,273,988

Phenotypes of a mutant

• cell lysis on agar plates [Pubmed|22229825]

RNA

Catalyzed reaction/ biological activity

• binds the ''[protein|search|bsrG]'' mRNA and triggers its degradation [Pubmed|22229825], moreover SR4 inhibits ''[protein|search|bsrG]'' [SW|translation] [Pubmed|23969414]

Expression and Regulation

Operon

• ''[SW|SR4]'' [Pubmed|22229825]

Sigma factor

• [SW|SigA] [Pubmed|22229825]

Additional information

• half-life of the RNA: 3 min [Pubmed|22229825]
• maturation of the RNA requires [protein|search|PnpA] [Pubmed|22229825]
• the RNA is degraded by [RNase Y|search|rny] and [RNase J1|search|rnjA] [Pubmed|]

Labs working on this gene/protein

• [SW|Sabine Brantl], Jena, Germany

References

• 18948176,20525796,23969414,22229825,26234942