SR4 [2019-05-12 18:09:46]

antitoxin RNA, inhibits bsrG translation and causes destabilization of the bsrG mRNA

locus: new_2273724_2273988_c

pI: 0.00

mw: 0.00 kDa

gene length: 265 bp

function: protection of the cell

product: antitoxin RNA

synonyms: SR4,S810

Genomic Context

categories

• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems]
• [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.5|Regulatory RNAs]

Gene

Coordinates: 2,273,724 → 2,273,988

Phenotypes of a mutant

• cell lysis on agar plates [Pubmed|22229825]

RNA

Catalyzed reaction/ biological activity

• binds the [gene|24A1B22DE468F187B6631D3D4E214B64CB8BB4DD|bsrG] mRNA and triggers its degradation [Pubmed|22229825], moreover SR4 inhibits [gene|24A1B22DE468F187B6631D3D4E214B64CB8BB4DD|bsrG] [SW|translation] [Pubmed|23969414]

Expression and Regulation

Operons

• genes: [gene|10A53E2465B5EAA307A099052FBBDF3B62857291|SR4]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|22229825], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  additional information

  • half-life of the RNA: 3 min [pubmed|22229825]
  • maturation of the RNA requires [protein|64C6D783FF3F41C81B216F798A1DC8071345B1ED|PnpA] [pubmed|22229825]

labs

• [SW|Sabine Brantl], Jena, Germany

References

• 18948176,20525796,23969414,22229825,26234942