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dctP
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dctP

uptake of succinate, fumurate, malate and oxaloacetate via proton symport
Locus
BSU_04470
Isoelectric point
8.67
Molecular weight
45.28 kDa
Protein length
421 aa Sequence Blast
Gene length
1266 bp Sequence Blast
Function
uptake of succinate, fumurate, malate and oxaloacetate
Product
C4-dicarboxylate transport protein
Essential
no
Synonyms
ydbH,dctA

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
500,166 501,431

The protein

Catalyzed reaction/ biological activity

  • uptake of succinate, fumurate, malate and oxaloacetate via proton symport PubMed
  • acts as co-sensor for DctS PubMed
  • Protein family

    Paralogous protein(s)

    Structure

  • 4KY0 (the glutamate transporter of Thermococcus kodakarensis, 31% identity, 71% similarity) PubMed
  • Localization

  • cell membrane (according to Swiss-Prot)
  • Expression and Regulation

    Operons

    Genes
    Description

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • Regulatory mechanism

  • CcpA: repression, PubMed, in CcpA regulon
  • Fur: indirect effect, in Fur regulon
  • Regulation

  • part of the iron sparing response, strong down-regulation in a fur mutant (Fur, FsrA) PubMed
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    Description

    Regulation

  • part of the iron sparing response, strong down-regulation in a fur mutant (Fur, FsrA) PubMed
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    Other regulations

  • FsrA: translation inhibition, PubMed
  • Biological materials

    Mutant

  • BKE04470 (dctP::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATCCTTCATCCCCCTGT, downstream forward: _UP4_TGAAAAAAGAACGGCCCATC
  • BKK04470 (dctP::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATATCCTTCATCCCCCTGT, downstream forward: _UP4_TGAAAAAAGAACGGCCCATC
  • GP2600 (dctP::tet comIQ12L) (in DK1042) available in Jörg Stülke's lab
  • References

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