SubtiBank SubtiBank
ylbQ
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ylbQ

2-dehydropantoate 2-reductase
Locus
BSU_15110
Isoelectric point
5.86
Molecular weight
33.13 kDa
Protein length
298 aa Sequence Blast
Gene length
897 bp Sequence Blast
Function
biosynthesis of coenzyme A
Product
2-dehydropantoate 2-reductase
Essential
no
E.C.
1.1.1.169
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of coenzyme A

    • Gene

    Coordinates
    1,577,409 1,578,305

    The protein

    Catalyzed reaction/ biological activity

  • (R)-pantoate + NADP+ --> 2-dehydropantoate + H+ + NADPH (according to UniProt)

    • Protein family

  • ketopantoate reductase family (with YkpB, according to UniProt)

    • Structure

  • 3LGO

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    ylbQ-bshC
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • Spx: activation, PubMed, in Spx regulon

    • Regulation

  • ylbQ: induced by diamide stess (thiol depletion) (Spx) PubMed
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    Biological materials

    Mutant

  • MGNA-B254 (ylbQ::erm), available at the NBRP B. subtilis, Japan
  • BKE15110 (ylbQ::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGATGTCACACCCAATTT, downstream forward: _UP4_TGAGCTTTTTCGGTAACATG
  • BKK15110 (ylbQ::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGATGTCACACCCAATTT, downstream forward: _UP4_TGAGCTTTTTCGGTAACATG

    • References

    Operon and expression

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