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cdd [2019-08-15 10:25:25]
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cdd [2019-08-15 10:25:25]

cytidine deaminase
locus
BSU_25300
pI
4.70
mw
14.71 kDa
protein length
136 aa Sequence Blast
gene length
411 bp Sequence Blast
function
pyrimidine interconversion
product
cytidine deaminase
essential
no
ec
3.5.4.5
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.4|Nucleotide metabolism/ other]

    • Gene

    Coordinates
    2,610,927 2,611,337

    The protein

    Catalyzed reaction/ biological activity

  • cytidine + H+ + H2O --> NH4+ + uridine (according to UniProt)
  • 2'-deoxycytidine + H+ + H2O --> 2'-deoxyuridine + NH4+ (according to UniProt)

    • Protein family

  • [SW|Cytidine and deoxycytidylate deaminase family] (according to UniProt)

    • [SW|Domains]

  • [SW|CMP/dCMP-type deaminase domain] (aa 1–122) (according to UniProt)

    • [SW|Cofactors]

  • Zn2+ [Pubmed|10891079]

    • Structure

  • [PDB|1JTK] (complex with inhibitor) [Pubmed|11851403]
  • [PDB|1UWZ] (with Arg56Ala substitution) [Pubmed|15147186]
  • [PDB|1UX0] (with Arg56Gln substitution) [Pubmed|15147186]
  • [PDB|1UX1] (with Cys53His and Arg56Gln substitutions) [Pubmed|15147186]

    • Expression and Regulation

    Operons

    genes
    [gene|0E9E9615CE056BEA2B65C494D946EB45F42A3064|cdd]-[gene|CB68B3393CA7862C45C624AF7B1ADD188243A01F|era]-[gene|33FBC31E8C24177137B0BDD8B46C1AFFD7F7B038|yqzL]-[gene|80E6F156764FF30300D034EE6FB44F2DB8338AF3|recO]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|6330116], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|6330116], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]
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    Biological materials

    Mutant

  • BKE25300 ([gene|0E9E9615CE056BEA2B65C494D946EB45F42A3064|cdd]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE25300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTACATTCCTCTCTT, downstream forward: _UP4_GGCGCATTTTCATCGGAGGA
  • BKK25300 ([gene|0E9E9615CE056BEA2B65C494D946EB45F42A3064|cdd]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK25300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTGTACATTCCTCTCTT, downstream forward: _UP4_GGCGCATTTTCATCGGAGGA

    • References

  • 10891079,10493793,11851403,15147186,2526291,10217788,6330116