tryptophanyl-tRNA synthetase
product
tryptophanyl-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
1,218,113 -> 1,219,105
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP L-tryptophan tRNA(Trp) = AMP diphosphate L-tryptophyl-tRNA(Trp) (according to Swiss-Prot)Protein family
class-I aminoacyl-tRNA synthetase family (according to Swiss-Prot)Structure
[PDB|3PRH] (Val144Pro mutant) [Pubmed|21224416][PDB|1BM2] (complex with tryptophan, ''Geobacillus stearothermophilus'')[PDB|1MAW] (complex with ATP, ''Geobacillus stearothermophilus'')[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''trpS'' [Pubmed|8915527]Regulation
induced by tryptophan limitation ([protein|search|T-box]) [Pubmed|8915527]Regulatory mechanism
[protein|search|T-box]: transcriptional antitermination in the absence of tryptophan (upon tRNA-binding to the mRNA leader region) [Pubmed|8915527]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|trpS]' and '[protein|search|oppA]' [PubMed|20525796]References
Reviews
Original publications
19258532,8932308,8915527,21224416,20525796,26555258 
