trpS [2019-04-02 12:35:36]

tryptophanyl-tRNA synthetase

Locus: BSU11420

Isoelectric point: 6.54

Molecular weight: 37.04 kDa

Protein length: 330 aa

Gene length: 993 bp

Function: translation

Product: tryptophanyl-tRNA synthetase

Essential: yes

E.C.: 6.1.1.2

Synonyms

Genomic Context

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Categories containing this gene/protein

• Information processing → Protein synthesis, modification and degradation → Translation → Aminoacyl-tRNA synthetases
• Groups of genes → Essential genes

Gene

Coordinates: 1,218,113 1,219,105

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP L-tryptophan tRNA(Trp) = AMP diphosphate L-tryptophyl-tRNA(Trp) (according to Swiss-Prot)

Protein family

• class-I aminoacyl-tRNA synthetase family (according to Swiss-Prot)

Structure

• 3PRH (Val144Pro mutant) PubMed
• 1BM2 (complex with tryptophan, Geobacillus stearothermophilus)
• 1MAW (complex with ATP, Geobacillus stearothermophilus)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: trpS
  Description: PubMed

  Regulation

  • induced by tryptophan limitation (T-box) PubMed

  Additional information

  • A ncRNA is predicted between trpS and oppA PubMed
  • the T-box RNA is degraded by RNase Y PubMed

References

Reviews

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Original publications

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