You are currently viewing an outdated version of
SubtiWiki.
Please use
the newest version!
trpS
tryptophanyl-tRNA synthetase
product
tryptophanyl-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
1,218,113 1,219,105
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP + L-tryptophan + tRNATrp --> AMP + diphosphate + H+ + L-tryptophanyl-tRNATrp (according to UniProt)Protein family
[SW|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)Structure
[PDB|3PRH] (Val144Pro mutant) [Pubmed|21224416][PDB|1BM2] (complex with tryptophan, ''Geobacillus stearothermophilus'')[PDB|1MAW] (complex with ATP, ''Geobacillus stearothermophilus'')[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|0D6CB84E74C32B0384BDC7740AA317EDEC5D60B6|trpS]
description
[Pubmed|8915527]
regulation
induced by tryptophan limitation ([protein|search|T-box]) [Pubmed|8915527]additional information
A [SW|ncRNA] is predicted between [gene|0D6CB84E74C32B0384BDC7740AA317EDEC5D60B6|trpS] and [gene|302DFA46D73E18C4663468ED6033C55056744475|oppA] [PubMed|20525796]the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]view in new tabReferences
Reviews
Original publications
19258532,8932308,8915527,21224416,20525796,26555258,27812824,29794222