Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|acquisition of iron], [SW|iron metabolism]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|PchR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,604,993 -> 3,605,502
Phenotypes of a mutant
inactivation of ''[SW|yvmB]'' causes widespread disruption of proteins involved in cellular processes that depend on iron availability, with pleiotropic effects on proteins associated with carbon metabolism, translation, stress response, biosynthesis of cell wall, and sporulation initiation [Pubmed|27542896]The protein
Protein family
MarR family of transcriptional regulators [Pubmed|27542896]Additional information
Proposed consensus sequence for DNA-binding site: GTTYMMYMGTAAAC [Pubmed|27542896]Expression and Regulation
Operon
''[protein|search|pchR]-[protein|search|yvmA]'' [Pubmed|22383849]Regulation
repressed by glucose (3.4-fold) ([protein|search|CcpA]) [Pubmed|12850135], subject to carbon catabolite repression (4-fold: [protein|search|CcpA]) [Pubmed|12850135]induced by iron starvation [Pubmed|27542896]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|12850135][protein|search|PchR] auto-repression [Pubmed|27542896]Biological materials
Mutant
BKE35080 ''pchR''::''erm trpC2'' is available from the Bacillus Genetic Stock CenterCS217 (''[protein|search|pchR]''::''aphA3'', available in [SW|Colin Harwood]'s and [SW|Jörg Stülke]'s labs) [Pubmed|27197833]Labs working on this gene/protein
Sandrine Auger, Micalis Institute, INRA, AgroParisTech, FranceReferences
12850135,22383849,27542896,27197833 
