function
biosynthesis of the siderophore bacillibactin
product
isochorismate synthase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.5|Other proteins required for biofilm formation][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue][SW|Categories] containing this gene/protein
[SW|acquisition of iron], [SW|iron metabolism], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|Fur regulon]Gene
Coordinates on the chromosome (coding sequence)
3,290,289 -> 3,291,485
The protein
Catalyzed reaction/ biological activity
Chorismate = isochorismate (according to Swiss-Prot)Protein family
isochorismate synthase family (according to Swiss-Prot)Modification
phosphorylation on Ser-271 [Pubmed|17218307]Structure
[PDB|3OS6], (from ''B. anthracis'', 56% identity, 70% similarity)Expression and Regulation
Operon
''[protein|search|dhbA]-[protein|search|dhbC]-[protein|search|dhbE]-[protein|search|dhbB]-[protein|search|dhbF]'' [Pubmed|8921902][SW|Sigma factor]
[protein|search|SigA] [Pubmed|8550523]Regulation
induced by iron starvation ([protein|search|Fur]) [Pubmed|12354229]Regulatory mechanism
[protein|search|Fur]: transcription repression [Pubmed|12354229][protein|search|AbrB]: transcription repression [Pubmed|20817675]Additional information
the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] [PubMed|21815947]the ''[protein|search|dhbA]-[protein|search|dhbC]-[protein|search|dhbE]-[protein|search|dhbB]-[protein|search|dhbF]'' operon is strongly unregulated in a ''[SW|kre]'' mutant [Pubmed|26110430]References
8224884,11112781,11790741,12354229,17218307,8921902,8550523,20817675,21815947,26110430 
