iseA [Tue Dec 13 2016 11:16:33 GMT+0100 (CET)]

inhibits in vitro activity of cell wall endopeptidases LytE and LytF, inhibits cell separation

locus: BSU18380

pI: 10.00

mw: 19.00 kDa

function: protection against cell envelope stress

product: inhibitor of autolysins

essential: no

synonyms: yoeB

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.1|Autolysis]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|cell wall degradation/ turnover], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|WalR regulon]

Gene

Coordinates on the chromosome (coding sequence): 2,002,637 -> 2,003,182

The protein

Structure

• [PDB|2RSX] [Pubmed|23091053]

[SW|Localization]

• cell membrane (according to Swiss-Prot), localized to cell separation sites

[SW|Interactions]

• [protein|search|IseA]-[protein|search|LytF] (catalytic domain) [Pubmed|18761694]

Expression and Regulation

Operon

• ''iseA'' [Pubmed|22383849]

Regulation

• repressed by [protein|search|WalR] [Pubmed|17581128]
• induced by vancomycin [Pubmed|17483219]
• strongly induced in response to glucose starvation in M9 medium [Pubmed|23033921]

Regulatory mechanism

• [protein|search|WalR]: transcription repression [Pubmed|17581128]

References

• 17581128,18761694,17483219,20059685,22383849,23091053,23033921,23199363