SubtiBank SubtiBank
iseA
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

iseA

inhibits in vitro activity of cell wall endopeptidases, inhibits cell separation
Locus
BSU_18380
Isoelectric point
10.18
Molecular weight
19.98 kDa
Protein length
181 aa Sequence Blast
Gene length
546 bp Sequence Blast
Function
protection against cell envelope stress
Product
inhibitor of autolysins
Essential
no
Synonyms
yoeB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
Loading

Categories containing this gene/protein

  • Cellular processes → Cell envelope and cell division → Cell wall degradation/ turnover → Autolysis
  • Groups of genes → Membrane proteins

    • Gene

    Coordinates
    2,002,637 2,003,182

    The protein

    Structure

  • 2RSX PubMed

    • Localization

  • localized to cell separation sites

    • Expression and Regulation

    Operons

    Genes
    iseA
    Description
    PubMed

    Regulatory mechanism

  • WalR: repression, PubMed, in WalR regulon

    • Regulation

  • expression is modulated in response to D,L-endopeptidase activity (decreased upon reduced activity in the absence of CwlO or FtsE-FtsX, increased upon overexpression of LytE) (WalR) PubMed
  • induced by vancomycin PubMed
    • view in new tab

    Additional information

  • the mRNA is cleaved by RNase III PubMed

    • Biological materials

    Mutant

  • MGNA-B076 (yoeB::erm), available at the NBRP B. subtilis, Japan
  • BKE18380 (iseA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTATCGCTCTCTCCTTCA, downstream forward: _UP4_TAAGAAAAACGCCCGGTATA
  • BKK18380 (iseA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTATCGCTCTCTCCTTCA, downstream forward: _UP4_TAAGAAAAACGCCCGGTATA

    • References

    Loading