nagB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

glucosamine-6-phosphate deaminase

locus: BSU35020

pI: 5.72

mw: 26.00 kDa

function: N-acetylglucosamine utilization

product: glucosamine-6-phosphate deaminase

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]
• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]

[SW|Categories] containing this gene/protein

• [SW|cell wall degradation/ turnover], [SW|utilization of specific carbon sources]

This gene is a member of the following [SW|regulons]

• [SW|NagR regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,596,543 -> 3,597,271

The protein

Catalyzed reaction/ biological activity

• D-glucosamine 6-phosphate + H₂O = D-fructose 6-phosphate + NH₃ (according to Swiss-Prot)

Protein family

• NagB subfamily (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|GamA]

Structure

• [PDB|2BKX][Pubmed|15755726]

Expression and Regulation

Operon

• ''[protein|search|nagA]-[protein|search|nagB]-[protein|search|nagR]'' [Pubmed|21602348]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|23667565]

Regulation

• induced in the presence of N-acetylglucosamine ([protein|search|NagR]) [Pubmed|24673833,21602348]

Regulatory mechanism

• [protein|search|NagR]: transcription repression [Pubmed|24673833,21602348]

References

Reviews

• 26159076

Original publications

• 6174502,15755726,21821766,21602348,23667565,24673833,23876412,25564531