yvcI [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

Nudix hydrolase

Locus: BSU34780

Isoelectric point: 4.00

Molecular weight: 18.00 kDa

Function: unknown

Product: unknown

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Nucleotide metabolism → Metabolism of signalling nucleotides
• Information processing → RNA synthesis and degradation → RNases → RNA pyrophosphohydrolase
• Information processing → Targets of second messengers → Targets of (p)ppGpp

Categories containing this gene/protein

• DNA repair/ recombination

This gene is a member of the following regulons

• CcpA regulon

Gene

Coordinates on the chromosome (coding sequence): 3,572,413 -> 3,572,889

The protein

Protein family

• Nudix hydrolase

Structure

• 3FK9 (the protein from B. halodurans, 59% identity/ 82% similarity)

Expression and Regulation

Operon

• yvcI-yvcJ-yvcK-yvcL-crh-yvcN PubMed

Sigma factor

• SigA PubMed

Regulation

• repressed by glucose (4.5-fold) (CcpA) PubMed, very weak stimuation of expression by citrate and succinate PubMed

Regulatory mechanism

• CcpA: transcription repression

Additional information

• A ncRNA is predicted between 'yvcI' and 'trxB' PubMed

Biological materials

Two-hybrid system

• B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab

References

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