yvcI [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

Nudix hydrolase

locus: BSU34780

pI: 4.00

mw: 18.00 kDa

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.3|Metabolism of signalling nucleotides]
• [category|SW 3|Information processing] → [category|SW 3.2|RNA synthesis and degradation] → [category|SW 3.2.4|RNases] → [category|SW 3.2.4.3|RNA pyrophosphohydrolase]
• [category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.3|Targets of (p)ppGpp]

[SW|Categories] containing this gene/protein

• [SW|DNA repair/ recombination]

This gene is a member of the following [SW|regulons]

• [SW|CcpA regulon]

Gene

Coordinates on the chromosome (coding sequence): 3,572,413 -> 3,572,889

The protein

Protein family

• [SW|Nudix hydrolase]

Structure

• [PDB|3FK9] (the protein from ''B. halodurans'', 59% identity/ 82% similarity)

Expression and Regulation

Operon

• ''[protein|search|yvcI]-[protein|search|yvcJ]-[protein|search|yvcK]-[protein|search|yvcL]-[protein|search|crh]-[protein|search|yvcN]'' [Pubmed|9237995]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|16272399]

Regulation

• repressed by glucose (4.5-fold) ([protein|search|CcpA]) [Pubmed|12850135], very weak stimuation of expression by citrate and succinate [Pubmed|16272399]

Regulatory mechanism

• [protein|search|CcpA]: transcription repression

Additional information

• A [protein|search|ncRNA] is predicted between '[protein|search|yvcI]' and '[protein|search|trxB]' [PubMed|20525796]

Biological materials

two-hybrid system

• ''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Jörg Stülke]'s lab

References

• 12850135,9237995,16272399,20525796