murQ [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

N-acetyl-muramic acid-6P etherase (cleaves lactate from N-acetylmuramic acid)

locus: BSU01700

pI: 5.00

mw: 32.00 kDa

function: cell wall turnover

product: N-acetyl-muramic acid-6P etherase

essential: no

synonyms: ybbI

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]
• [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]

[SW|Categories] containing this gene/protein

• [SW|cell wall degradation/ turnover], [SW|utilization of specific carbon sources], [SW|phosphoproteins], [SW|sporulation proteins]

Gene

Coordinates on the chromosome (coding sequence): 192,051 -> 192,965

Phenotypes of a mutant

• strongly reduced viability during prolonged incubation in stationary phase [Pubmed|27729505]

The protein

Catalyzed reaction/ biological activity

• N-acetylmuramic acid 6-phosphate H₂O = N-acetyl-D-glucosamine 6-phosphate D-lactate (according to Swiss-Prot)

Protein family

• SIS domain (according to Swiss-Prot)

Modification

• phosphorylation on Ser-2 [Pubmed|17218307]

Expression and Regulation

Operon

• ''[protein|search|murQ]-[protein|search|murR]-[protein|search|murP]-[protein|search|amiE]-[protein|search|nagZ]-[protein|search|ybbC]'' [Pubmed|22383849]

References

• 17218307,20400549,22383849,27729505