murJ [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

lipid II flippase

locus: BSU30050

pI: 10.00

mw: 59.00 kDa

function: export of lipid II

product: lipid II flippase

essential: no

synonyms: ytgP

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|biosynthesis of cell wall components], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence): 3,073,531 -> 3,075,165

Phenotypes of a mutant

• an ''[protein|search|amj] [protein|search|murJ]'' double mutant is not viable [Pubmed|25918422]
• a ''[protein|search|sigM] [protein|search|murJ]'' double mutant is not viable (due to the lack of both lipid II flippases) [Pubmed|25918422]
• mutants lacking [protein|search|MurJ] produce long cells and chains of cells [Pubmed|19648239]

The protein

Protein family

• [SW|MOP exporter family]

Paralogous protein(s)

• [SW|SpoVB], [protein|search|YabM], [protein|search|YkvU]

Biological materials

Mutant

• MGNA-A012 (ytgP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/12 NBRP B. subtilis, Japan]

References

Reviews

• 26679002

Original Publications

• 19648239,19666716,25918422