phenylalanyl-tRNA synthetase (alpha subunit), universally conserved protein
product
phenylalanyl-tRNA synthetase (alpha subunit)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes], [SW|universally conserved proteins], [SW|most abundant proteins]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Coordinates on the chromosome (coding sequence)
2,929,438 -> 2,930,472
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP L-phenylalanine tRNA(Phe) = AMP diphosphate L-phenylalanyl-tRNA(Phe) (according to Swiss-Prot) Protein family
Phe-tRNA synthetase alpha chain type 1 subfamily (according to Swiss-Prot)Structure
[PDB|1PYS] (from ''Thermus thermophilus hb8 mutant'', 37% identity, 56% similarity) [Pubmed|7664121][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|PheS]-[protein|search|PheT]Additional information
[SW|universally conserved protein]Expression and Regulation
Operon
''[protein|search|pheS]-[protein|search|pheT]'' [Pubmed|2127701][SW|Sigma factor]
[protein|search|SigA] [Pubmed|2127701]Regulation
induced by phenylalanine limitation ([protein|search|T-box]) [Pubmed|19258532]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|19258532]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
19258532,2127701,15378759 
