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sipW [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]
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sipW [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

bifunctional signal peptidase I that controls surface-adhered biofilm formation and processes TasA and TapA
locus
BSU24630
pI
5.49
mw
20.00 kDa
function
biofilm formation
product
signal peptidase I
essential
no
synonyms
yqhE
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.2|Biofilm formation] → [category|SW 4.1.2.2|Amyloid protein synthesis, secretion and assembly]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|protein secretion], [SW|biofilm formation], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|RemA regulon], [SW|SinR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,553,930 -> 2,554,502

    The protein

    Catalyzed reaction/ biological activity

  • important for [SW|biofilm formation] on a solid surface, but not required at an air-liquid interface [Pubmed|22328672]
  • Cleavage of hydrophobic, N-terminal signal or leader sequences from [protein|search|TasA] and [protein|search|TapA] [Pubmed|10049401,10559173]

    • Protein family

  • peptidase S26B family (according to Swiss-Prot)

    • [SW|Localization]

  • membrane [Pubmed|22328672]

    • [SW|Interactions]

  • [protein|search|SipW]-[protein|search|TapA] [Pubmed|10559173]
  • [protein|search|SipW]-[protein|search|TasA] [Pubmed|10049401]

    • Expression and Regulation

    Operon

  • ''[protein|search|tapA]-[protein|search|sipW]-[protein|search|tasA]'' [Pubmed|16430695]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|16430695]

    • Regulation

  • repressed by [protein|search|SinR] [Pubmed|16430695]
  • repressed during logrithmic growth ([protein|search|AbrB]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]

    • Regulatory mechanism

  • [protein|search|AbrB]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]
  • [protein|search|SinR]: transcription repression [Pubmed|16430695]
  • [protein|search|RemA]: transcription activation [Pubmed|23646920]

    • Additional information

  • induction by sequestration of [protein|search|SinR] by [protein|search|SinI] or [protein|search|SlrA] [PubMed|15661000,19788541] or by [protein|search|SlrR] [PubMed|20351052]
  • the '[protein|search|tapA]-[protein|search|sipW]-[protein|search|tasA]' operon is not expressed in a '[protein|search|ymdB]' mutant [PubMed|21856853]
  • the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] (this is likely due to the increased stability of the '[protein|search|sinR]' mRNA) [PubMed|21815947]

    • Biological materials

    Mutant

  • 1A937 ( ''sipW''::''kan''), [Pubmed|15101989], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A937&Search=1A937 BGSC]

    • Labs working on this gene/protein

  • [SW|Beth Lazazzera], Los Angeles, USA

    • References

    Reviews

  • 21488983,22427624,22688815

    • Original publications

  • 22328672,18047568,15175311,16430695,10368135,9694797,18430133,18647168,10464223,17720793,20351052,10827084,21477127,10559173,23646920,21856853,21815947