scr [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

4.5 S RNA, causes RNA-driven elongation arrest by interaction with the 23S rRNA

locus: BSU_misc_RNA_2

pI: 0.00

mw: 0.00 kDa

function: presecretory protein translocation

product: small cytoplasmic RNA (scRNA, 4.5S RNA)

essential: yes

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
• [category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.3|Small cytoplasmatic RNA]

[SW|Categories] containing this gene/protein

• [SW|protein secretion], [SW|essential genes], [SW|ncRNA]

Gene

Coordinates on the chromosome (coding sequence): 26,533 -> 26,635

Phenotypes of a mutant

• the gene is essential [Pubmed|7506707]

The protein

Catalyzed reaction/ biological activity

• === Extended information on the RNA===

Structure

• [PDB|4UE4] (complex [protein|search|Ffh]-[protein|search|Scr] RNA) [Pubmed|26344568]

[SW|Interactions]

• [protein|search|Scr]-[protein|search|Ffh] in the [SW|signal recognition particle] [Pubmed|26344568]
• [protein|search|Scr]-[[23S rRNA]] [Pubmed|26344568]

Expression and Regulation

Operon

• ''[protein|search|yaaJ]-[protein|search|scr], [protein|search|scr]

[SW|Sigma factor]

• [protein|search|SigA] (both promoters)

Labs working on this gene/RNA

• [SW|David Bechhofer], Mount Sinai School, New York, USA [http://www.mountsinai.org/Research/Centers Laboratories and Programs/Bechhofer Laboratory?citype=Physician&ciid=Bechhofer David H 1255565 Homepage]

References

Reviews

• 25212246

Original publications

• 9346318,2468993,17576666,1372600,7506707,1383945,7538759,10224127,9677377,8662730,10222262,25270875,25402410,26344568,26883633