bceS [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

two-component sensor kinase, regulation of bceA-bceB in response to bacitracin, plectasin, mersacidin and actagardine

locus: BSU30390

pI: 5.00

mw: 38.00 kDa

function: resistance against toxic peptides

product: two-component sensor kinase (OmpR family)

essential: no

synonyms: ytsB

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

[SW|Categories] containing this gene/protein

• [SW|protein modification], [SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins], [SW|phosphoproteins]

Gene

Coordinates on the chromosome (coding sequence): 3,112,190 -> 3,113,194

The protein

Catalyzed reaction/ biological activity

• autophosphorylation, phosphorylation of [protein|search|BceR]

[SW|Domains]

• two transmembrane segments, C-terminal histidine phosphotransferase domain

Modification

• autophosphorylation on a His residue

Effectors of protein activity

• binding of [protein|search|BceB] in the absence of bacitracin inhibits [protein|search|BceS] autophosphorylation [Pubmed|25118291]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|BceS]-[protein|search|BceR] [Pubmed|25118291]
• [protein|search|BceB]-[protein|search|BceS], in the absence of bacitracin [Pubmed|25118291,23687272,21283517]

Expression and Regulation

Operon

• ''[protein|search|bceR]-[protein|search|bceS]'' [Pubmed|12399481]

Biological materials

Mutant

• MGNA-A166 (ytsB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/166 NBRP B. subtilis, Japan]

References

Reviews

• 27344142

Original publications

• 10094672,18394148,12890034,14651641,21283517,20606066,22964256,21078927,17905982,23687272,25118291,26199330