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bceS [2017-8-11 16:0:3]
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bceS [2017-8-11 16:0:3]

two-component sensor kinase, regulation of bceA-bceB in response to bacitracin, plectasin, mersacidin and actagardine
locus
BSU30390
pI
5.94
mw
38.61 kDa
protein length
334 aa Sequence Blast
gene length
1002 bp Sequence Blast
function
resistance against toxic peptides
product
two-component sensor kinase (OmpR family)
essential
no
synonyms
ytsB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]

    • Gene

    Coordinates
    3,112,190 → 3,113,194

    The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation, phosphorylation of [protein|C239C155F5452C86BF6C78190BABBBB07A63DF87|BceR]

    • [SW|Domains]

  • two transmembrane segments, C-terminal histidine phosphotransferase domain

    • Modification

  • autophosphorylation on a His residue

    • Effectors of protein activity

  • binding of [protein|E3613A6C8B5F0EC76510ACE3E478967E73E2B241|BceB] in the absence of bacitracin inhibits [protein|08F24CA21DC54031F6158AC0C772F3B520E5A849|BceS] autophosphorylation [Pubmed|25118291]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|C239C155F5452C86BF6C78190BABBBB07A63DF87|bceR]-[gene|08F24CA21DC54031F6158AC0C772F3B520E5A849|bceS]
    description
    [Pubmed|12399481]
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    Biological materials

    Mutant

  • MGNA-A166 (ytsB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/166 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 27344142,28152228

    • Original publications

  • 10094672,18394148,12890034,14651641,21283517,20606066,22964256,21078927,17905982,23687272,25118291,26199330