mciZ [Tue Oct 25 2016 11:38:17 GMT+0200 (CEST)]

FtsZ inhibition peptide

locus: BSU23616

pI: 0.00

mw: 4.00 kDa

function: inhibits GTPase activity of FtsZ and Z ring formation during sporulation

product: FtsZ inhibition peptide

essential: no

synonyms: S896

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]

[SW|Categories] containing this gene/protein

• [SW|cell division], [SW|sporulation proteins], [SW|short peptides]

This gene is a member of the following [SW|regulons]

• [SW|SigE regulon]

Gene

Coordinates on the chromosome: 2,459,114 -> 2,459,288

Protein

Catalyzed reaction/ biological activity

• inhibits GTPase activity of [SW|FtsZ]and Z ring formation during [SW|sporulation]

Structure

• [PDB|2MRW] [Pubmed|25848052]
• [PDB|4U39] (the [SW|MciZ]-[SW|FtsZ] complex) [Pubmed|25848052]

[SW|Interactions]

• [SW|MciZ]-[SW|FtsZ] [Pubmed|18284588], K_D 150 nM [Pubmed|25848052]

Expression and Regulation

Sigma factor

• [SW|SigE] [Pubmed|18284588]

Regulation

• expressed early during sporulation in the mother cell ([SW|SigE]) [Pubmed|18284588]

References

Reviews

• 19680248

Original publications

• 18284588,25848052,23237472