csbC

general stress protein, similar to sugar-H⁺ symporter, required for protection against paraquat stress

Locus: BSU_39810

Isoelectric point: 9.94

Molecular weight: 49.97 kDa

Protein length: 461 aa

Gene length: 1386 bp

Function: protection against paraquat stress

Product: putative sugar-H⁺ symporter

Essential: no

Synonyms: yxcC

Genomic Context

Loading

Categories containing this gene/protein

• Cellular processes → Transporters → Transporters/ other → Other transporters
• Lifestyles → Coping with stress → General stress proteins (controlled by SigB)
• Lifestyles → Coping with stress → Resistance against oxidative and electrophile stress
• Groups of genes → Membrane proteins

Gene

Coordinates: 4,088,002 4,089,387

The protein

Protein family

• major facilitator superfamily (according to UniProt)
• Sugar transporter (TC 2.A.1.1) family (according to UniProt)

Paralogous protein(s)

• CsbC, IolT, AraE, YwtG, YfiG, YncC, CsbC

Domains

• contains 12 trans-membrane domains PubMed

Structure

• 4LDS (from Staphylococcus epidermidis, 54% identity) PubMed

Localization

• homogeneously distributed in the cell membrane PubMed

Expression and Regulation

Operons

• Genes: csbC

  Sigma factors

  • SigB: sigma factor, PubMed, in SigB regulon

  Regulation

  • induced by stress (sigB) PubMed

Biological materials

Mutant

• MGNA-B695 (yxcC::erm), available at the NBRP B. subtilis, Japan
• BKE39810 (csbC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACAAATGTCTCCTCCTCAG, downstream forward: _UP4_TAAAAAAAGGAATCGTCTCC
• BKK39810 (csbC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACAAATGTCTCCTCCTCAG, downstream forward: _UP4_TAAAAAAAGGAATCGTCTCC

References

Loading