acetyl-CoA C-acyltransferase
function
fatty acid degradation
product
acetyl-CoA C-acyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][SW|Categories] containing this gene/protein
[SW|utilization of lipids], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|FadR regulon], [SW|SdpR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,368,839 -> 3,370,014
The protein
Catalyzed reaction/ biological activity
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA (according to Swiss-Prot)Protein family
thiolase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|MmgA], [protein|search|YhfS]Structure
[PDB|3SS6] (the protein of ''B. anthracis'', 41% identity, 73% similarity)Expression and Regulation
Operon
''[protein|search|fadM]-[protein|search|fadN]-[protein|search|fadA]-[protein|search|fadE]'' [Pubmed|17189250]''[protein|search|fadN]-[protein|search|fadA]-[protein|search|fadE]'' [Pubmed|17189250][SW|Sigma factor]
''[protein|search|fadN]'': [protein|search|SigA] [Pubmed|17189250]Regulation
''[protein|search|fadN]'': induced by long-chain fatty acids ([protein|search|FadR]) [Pubmed|17189250]''[protein|search|fadN]'': subject to carbon catabolite repression ([protein|search|CcpA]-[PtsH|search|HPr(Ser-P)] [Pubmed|21398533]Regulatory mechanism
[protein|search|FadR]: transcription repression [Pubmed|17189250][protein|search|SdpR]: transcription activation [Pubmed|12817086][protein|search|CcpA]-[PtsH|search|HPr(Ser-P)]: transcription repression [Pubmed|21398533]References
17189250,12817086,17919287 
