SubtiBank SubtiBank
metI [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

metI [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

O-succinylhomoserine lyase (L-cysteine, H2S, methanethiol, elimination)
locus
BSU11870
pI
5.02
mw
41.00 kDa
function
biosynthesis of methionine
product
O-succinylhomoserine lyase
(L-cysteine, H2S, methanethiol, elimination)
essential
no
synonyms
yjcI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]

    • This gene is a member of the following [SW|regulons]

  • [SW|S-box]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,258,492 -> 1,259,613

    Expression and Regulation

    Operon

  • ''[protein|search|metI]-[protein|search|metC]'' [Pubmed|11832514]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|11832514]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]

    • Regulatory mechanism

  • [protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]

    • Biological materials

    Mutant

  • 1A941 ( ''metI''::''spec''), [Pubmed|11832514], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A941&Search=1A941 BGSC]

    • References

  • 19258532,11832514,10094622,11948165,12107147,18039762