metQ [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

methionine ABC transporter (binding lipoprotein)

Locus: BSU32730

Isoelectric point: 8.00

Molecular weight: 30.00 kDa

Function: methionine uptake

Product: methionine ABC transporter (binding lipoprotein)

Essential: no

Synonyms: yusA

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → ABC transporters → Importers → Uptake of amino acids
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of methionine/ S-adenosylmethionine
• Groups of genes → Secreted proteins
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

• CodY regulon, S-box

Gene

Coordinates on the chromosome (coding sequence): 3,361,767 -> 3,362,591

The protein

Paralogous protein(s)

• YhcJ

Structure

• 4GOT

Localization

• associated to the cell membrane, via MetP PubMed
• extracellular (signal peptide) PubMed, lipid modification as retention signal

Interactions

• MetN-MetP-MetQ PubMed
• McpC-MetQ, for chemotaxis to methionine PubMed

Expression and Regulation

Operon

• metN-metP-metQ PubMed

Regulation

• activated during growth in the presence of branched chain amino acids (CodY) PubMed
• induced by methionine starvation (S-box) PubMed

Regulatory mechanism

• S-box: transcription termination/ antitermination, the S-box riboswitch binds S-adenosylmethionine resulting in termination PubMed
• CodY: transcription activation PubMed

References

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