methionine ABC transporter (binding lipoprotein)
function
methionine uptake
product
methionine ABC transporter (binding lipoprotein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine][category|SW 6|Groups of genes] → [category|SW 6.12|Secreted proteins][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|CodY regulon], [SW|S-box]Gene
Coordinates on the chromosome (coding sequence)
3,361,767 -> 3,362,591
The protein
Paralogous protein(s)
[protein|search|YhcJ]Structure
[PDB|4GOT][SW|Localization]
associated to the cell membrane, via [protein|search|MetP] [Pubmed|10092453,18763711]extracellular (signal peptide) [Pubmed|18957862], lipid modification as retention signal[SW|Interactions]
[protein|search|MetN]-[protein|search|MetP]-[protein|search|MetQ] [Pubmed|10092453][protein|search|McpC]-[protein|search|MetQ], for chemotaxis to methionine [Pubmed|23038252]Expression and Regulation
Operon
''[protein|search|metN]-[protein|search|metP]-[protein|search|metQ]'' [Pubmed|10094622]Regulation
activated during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]Regulatory mechanism
[protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622][protein|search|CodY]: transcription activation [Pubmed|12618455]References
10092453,14990259,12618455,18957862,18763711,10094622,18039762,23038252 
