SubtiBank SubtiBank
degS [Mon Aug 31 2015 13:57:05 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

degS [Mon Aug 31 2015 13:57:05 GMT+0200 (CEST)]

two-component sensor kinase for exoenzyme and competence regulation, kinase activity is activated in response to inhibition of flagellar rotation
locus
BSU35500
pI
5.99
mw
44.00 kDa
function
regulation of degradative enzyme and genetic competence
product
two-component sensor kinase
essential
no
synonyms
sacU
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.1|Two-component sensor kinase]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.4|Phosphorylation on a His residue]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.5|Phosphorylation on a Ser residue]
    • syns
    sacU

    [SW|Categories] containing this gene/protein

  • [SW|protein modification], [SW|transcription factors and their control], [SW|phosphoproteins]

    • Gene

    Phenotypes of a mutant

  • the mutation suppresses the mucoid phenotype of ''[protein|search|motA]'' or ''[protein|search|motB]'' mutants due to loss of [protein|search|DegU] phosphorylation and concomitant reduced expression of the ''[protein|search|capB]-[protein|search|capC]-[protein|search|capA]-[protein|search|capE]'' operon [Pubmed|24296669]

    • The protein

    Catalyzed reaction/ biological activity

  • autophosphorylation, autodephosphorylation, phosphorylation of [protein|search|DegU] on Asp-56 [Pubmed|1901568]

    • [SW|Domains]

  • aa 12 ... 170: unknown DegS domain
  • aa 180 ... 248: HisKA_3 domain (autophosphorylation)
  • aa 289 ... 384: HATPase_c

    • Modification

  • phosphorylation on Ser-76 [Pubmed|17218307], this stimulates phosphotransfer from His-189 to [protein|search|DegU] [Pubmed|21304896], the phosphorylyation is performed by [protein|search|PrkD] ''in vitro'' [Pubmed|21304896]
  • autophosphorylation on His-189

    • Effectors of protein activity

  • [protein|search|DegQ] (stimulation of autophosphorylation) [Pubmed|21965392]
  • inhibition of flagellar rotation stimulates kinase activity [Pubmed|23888912]

    • [SW|Localization]

  • Cytoplasm (Homogeneous) [Pubmed|16479537]

    • [SW|Interactions]

  • [protein|search|DegS]-[protein|search|DegU]
  • [protein|search|DegS]-[protein|search|DegQ] [Pubmed|21965392]

    • Expression and Regulation

    Operon

  • ''[protein|search|degS]-[protein|search|degU]'' [Pubmed|1688843]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1688843]

    • Labs working on this gene/protein

  • [SW|Tarek Msadek], Institut Pasteur, Paris, France

    • References

    Reviews

  • 23927648

    • Original Publications

  • 17850253,12471443,14563871,1459944,1901568,10094672,1688843,16479537,17218307,21304896,21965392,24296669,23888912,25433860