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ligA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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ligA [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

DNA ligase (NAD-dependent)
locus
BSU06620
pI
4.00
mw
74.00 kDa
function
replication
product
DNA ligase (NAD-dependent)
essential
yes
ec
6.5.1.2
synonyms
lig, yerG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|DNA replication], [SW|essential genes]

    • This gene is a member of the following [SW|regulons]

  • [SW|LexA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    721,613 -> 723,619

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • NAD (deoxyribonucleotide)(n) (deoxyribonucleotide)(m) = AMP nicotinamide nucleotide (deoxyribonucleotide)(nm) (according to Swiss-Prot)

    • Protein family

  • BRCT domain (according to Swiss-Prot)

    • Structure

  • [PDB|1B04] (adenylation domain, Geobacillus stearothermophilus)

    • Expression and Regulation

    Operon

  • ''[protein|search|pcrB]-[protein|search|pcrA]-[protein|search|ligA]-[protein|search|yerH]'' [Pubmed|9701819]

    • Regulation

  • induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]

    • Regulatory mechanism

  • [protein|search|LexA]: transcription repression [Pubmed|16267290]

    • Biological materials

    Mutant

  • MGNA-B444 (yerG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1443 NBRP B. subtilis, Japan]

    • References

  • 11095673,16267290,9701819