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ligA [2019-09-05 09:43:40]
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ligA [2019-09-05 09:43:40]

DNA ligase (NAD-dependent)
Locus
BSU_06620
Isoelectric point
4.71
Molecular weight
74.69 kDa
Protein length
668 aa Sequence Blast
Gene length
2007 bp Sequence Blast
Function
replication
Product
DNA ligase (NAD-dependent)
Essential
yes
E.C.
6.5.1.2
Synonyms
lig,yerG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → DNA replication
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    721,613 723,619

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • NAD(+) + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) --> (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotid (according to UniProt)

    • Protein family

  • NAD-dependent DNA ligase family (single member, according to UniProt)

    • Structure

  • 1B04 (adenylation domain, Geobacillus stearothermophilus)

    • Expression and Regulation

    Operons

    Genes
    pcrB-pcrA-ligA-yerH
    Description
    PubMed

    Regulatory mechanism

  • LexA: repression, PubMed, in LexA regulon

    • Regulation

  • induced by DNA damage (LexA) PubMed
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    Biological materials

    Mutant

  • MGNA-B444 (yerG::erm), available at the NBRP B. subtilis, Japan

    • References

    Reviews

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    Original publications

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