cspR [Tue Feb 14 2017 12:31:17 GMT+0100 (CET)]

similar to tRNA (Um34/Cm34) methyltransferase

locus: BSU08930

pI: 6.00

mw: 18.00 kDa

function: translation

product: tRNA (Um34/Cm34) methyltransferase homolog

essential: no

ec: 2.1.1.-

synonyms: ygaR, trmL

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]

[SW|Categories] containing this gene/protein

• [SW|translation], [SW|essential genes]

This gene is a member of the following [SW|regulons]

• [SW|SigE regulon]

Gene

Coordinates on the chromosome (coding sequence): 970,135 -> 970,617

Phenotypes of a mutant

• essential [Pubmed|12682299], non-essential according to [Pubmed|28189581]

The protein

Catalyzed reaction/ biological activity

• catalyzes the methyl transfer from S-adenosyl-L-methionine to tRNA(Leu)(CAA) and tRNA(Leu)(UAA) isoacceptors [Pubmed|23804755]

Structure

• [PDB|4JAK] (from ''E. coli'', 45% identity, 72% similarity) [Pubmed|23804755]

Expression and Regulation

Operon

• ''[SW|yhbB]-[SW|cspR]'' [Pubmed|12662922]
• ''[SW|cspR]'' [Pubmed|22383849]

[SW|Sigma factor]

• ''[SW|yhbB]-[SW|cspR]'': [SW|SigE] [Pubmed|12662922]

Regulation

• ''[SW|yhbB]-[SW|cspR]'': expressed in the mother cell early during [SW|sporulation] ([SW|SigE]) [Pubmed|12662922]

References

• 23804755,12662922,22383849,28189581