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hisD [2019-08-09 13:45:15]
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hisD [2019-08-09 13:45:15]

histidinol dehydrogenase
locus
BSU_34910
pI
4.78
mw
46.09 kDa
protein length
427 aa Sequence Blast
gene length
1284 bp Sequence Blast
function
biosynthesis of histidine
product
histidinol dehydrogenase
essential
no
ec
1.1.1.23
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]

    • Gene

    Coordinates
    3,586,271 3,587,554

    The protein

    Catalyzed reaction/ biological activity

  • L-histidinol + 2 NAD+ = L-histidine + 2 NADH (according to Swiss-Prot)

    • Protein family

  • histidinol dehydrogenase family (single member, according to UniProt)

    • Structure

  • [PDB|1KAH] (with product and NAD from ''Escherichia coli'', 39% identity, 58% similarity) [Pubmed|11842181]

    • Expression and Regulation

    Operons

    genes
    [gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]-[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]-[gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]-[gene|88ED20DFEBD5D7B985F99D4494142FBA699A1E91|hisB]-[gene|DEB3122A3EA36545759FAA6F86F71F971CA5F011|hisH]-[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]-[gene|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]-[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]
    description
    [Pubmed|12107147]

    regulatory mechanism

  • [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]

    • regulation

  • expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
  • expression depends on functional [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]
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    Biological materials

    Mutant

  • BKE34910 ([gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE34910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCTCCGCTGATGGTTTTGA, downstream forward: _UP4_GCGAGAGAACGGAGGATTTC
  • BKK34910 ([gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK34910 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCTCCGCTGATGGTTTTGA, downstream forward: _UP4_GCGAGAGAACGGAGGATTTC

    • References

  • 12107147,27766092