hisD [Tue Oct 25 2016 16:58:57 GMT+0200 (CEST)]

histidinol dehydrogenase

locus: BSU34910

pI: 4.00

mw: 46.00 kDa

function: biosynthesis of histidine

product: histidinol dehydrogenase

essential: no

ec: 1.1.1.23

synonyms

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids]

Gene

Coordinates on the chromosome (coding sequence): 3,586,271 -> 3,587,554

The protein

Catalyzed reaction/ biological activity

• L-histidinol 2 NAD = L-histidine 2 NADH (according to Swiss-Prot)

Protein family

• histidinol dehydrogenase family (according to Swiss-Prot)

Structure

• [PDB|1KAH] (with product and NAD from ''Escherichia coli'', 39% identity, 58% similarity) [Pubmed|11842181]

Expression and Regulation

Operon

• ''[protein|search|hisZ]-[protein|search|hisG]-[protein|search|hisD]-[protein|search|hisB]-[protein|search|hisH]-[protein|search|hisA]-[protein|search|hisF]-[protein|search|hisI]'' [Pubmed|12107147]

Regulation

• repressed by casamino acids [Pubmed|12107147]

References

• 12107147