diaminopimelate decarboxylase
function
biosynthesis of lysine
product
diaminopimelate decarboxylase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|sporulation proteins]This gene is a member of the following [SW|regulons]
[SW|SigG regulon], [SW|SpoVT regulon]Gene
Phenotypes of a mutant
auxotrophic for lysine [Pubmed|15574923]reduced conjugation of ICEBs1 [Pubmed|25069588]The protein
Catalyzed reaction/ biological activity
Meso-2,6-diaminoheptanedioate = L-lysine + CO2 (according to Swiss-Prot)Protein family
Orn/Lys/Arg decarboxylase class-II family (according to Swiss-Prot)Structure
[PDB|1HKW] (from ''Mycobacterium tuberculosis'', 42% identity, 61% similarity) [Pubmed|12637582]Expression and Regulation
Operon
''[SW|spoVAA]-[SW|spoVAB]-[SW|spoVAC]-[SW|spoVAD]-[SW|spoVAEB]-[SW|spoVAEA]-[SW|spoVAF]-[protein|search|lysA]'' [Pubmed|7934830][SW|Sigma factor]
[protein|search|SigG] [Pubmed|15699190,1903432]Regulation
expressed late during sporulation in the forespore ([protein|search|SigG], [SW|SpoVT]) [Pubmed|15699190,1903432,8755877]Regulatory mechanism
[SW|SpoVT]: transcription activation [Pubmed|8755877]Biological materials
Mutant
1A615 ( ''lysA''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A615&Search=1A615 BGSC]References
7934830,15574923,15699190,1903432,8755877,25069588 
