rplD [Fri Jan 29 2016 16:46:16 GMT+0100 (CET)]

ribosomal protein

locus: BSU01170

pI: 10.00

mw: 22.00 kDa

function: translation

product: ribosomal protein L4

essential: yes

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|translation], [SW|essential genes]

This gene is a member of the following [SW|regulons]

• [SW|stringent response]

Gene

Coordinates on the chromosome (coding sequence): 136,369 -> 136,992

Phenotypes of a mutant

• essential [Pubmed|23002217,12682299]

The protein

Protein family

• [SW|ribosomal protein] L4P family (according to Swiss-Prot)

[SW|Interactions]

• [protein|search|RplD]-[protein|search|MifM] [Pubmed|25903689]

Expression and Regulation

Operon

• ''[protein|search|rpsJ]-[protein|search|rplC]-[protein|search|rplD]-[protein|search|rplW]-[protein|search|rplB]-[protein|search|rpsS]-[protein|search|rplV]-[protein|search|rpsC]-[protein|search|rplP]-[protein|search|rpmC]-[protein|search|rpsQ]-[protein|search|rplN]-[protein|search|rplX]-[protein|search|rplE]-[protein|search|rpsN]-[protein|search|rpsH]-[protein|search|rplF]-[protein|search|rplR]-[protein|search|rpsE]-[protein|search|rpmD]-[protein|search|rplO]'' [Pubmed|9371452]

[SW|Sigma factor]

• [protein|search|SigA] two promoters, about 140bp and 200bp upstream of the start codon [Pubmed|9371452]

Regulation

• [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

Biological materials

two-hybrid system

• B. pertussis adenylate cyclase-based bacterial two hybrid system ([SW|BACTH]), available in [SW|Stülke] lab

References

• 19653700,9371452,11948165,8635744,23002217,25903689