xanthine phosphoribosyltransferase
function
purine salvage and interconversion
product
xanthine phosphoribosyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.3|Purine salvage and interconversion][category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.3|Targets of (p)ppGpp][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|G-box], [SW|PurR regulon]Gene
Coordinates on the chromosome (coding sequence)
2,319,440 -> 2,320,024
The protein
Catalyzed reaction/ biological activity
XMP diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate xanthine (according to Swiss-Prot)Structure
[PDB|1Y0B], [PDB|2FXV] (complex with GMP), [PDB|1Y27] (the riboswitch in complex with guanine)[SW|Localization]
cell membrane (according to Swiss-Prot)Additional information
subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]Expression and Regulation
Operon
''[protein|search|xpt]-[protein|search|pbuX]'' [Pubmed|9098051][SW|Sigma factor]
[protein|search|SigA] [Pubmed|9098051]Regulation
repressed in the presence of adenine or adenosine ([protein|search|PurR]) [Pubmed|11591660]induced in the absence of guanine ([SW|G-box]) [Pubmed|12787499]Regulatory mechanism
[SW|G-box]: transcription termination/ antitermination ([SW|riboswitch]) [Pubmed|9098051,12787499][protein|search|PurR]: transcription repression (molecular inducer: PRPP) [Pubmed|11591660]Additional information
subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]Biological materials
lacZ fusion
pGP430 (in [SW|pAC7]), available in [SW|Jörg Stülke]'s labReferences
16716072,9098051,12923093,15629952,11591660,15610857,20200045,11591660,20204714,26704707 
