SubtiBank SubtiBank
araA [Mon Aug 31 2015 13:56:09 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

araA [Mon Aug 31 2015 13:56:09 GMT+0200 (CEST)]

L-arabinose isomerase
locus
BSU28800
pI
5.47
mw
56.00 kDa
function
arabinose utilization
product
L-arabinose isomerase
essential
no
ec
5.3.1.4
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.6|Utilization of arabinan/ arabinose/ arabitol]
  • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources]
  • This gene is a member of the following [SW|regulons]

  • [SW|AraR regulon], [SW|CcpA regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • L-arabinose = L-ribulose (according to Swiss-Prot)
  • Protein family

  • arabinose isomerase family (according to Swiss-Prot)
  • Kinetic information

  • k (cat) of 14,504 min(-1) and k (cat)/K (m) of 121 min(-1) mM(-1) for L-arabinose [Pubmed|19727704]
  • Structure

  • [PDB|2AJT] (from ''Escherichia coli'', 51% identity, 71% similarity) [Pubmed|16756997]
  • Expression and Regulation

    Operon

  • ''[protein|search|araA]-[protein|search|araB]-[protein|search|araD]-[protein|search|araL]-[protein|search|araM]-[protein|search|araN]-[protein|search|araP]-[protein|search|araQ]-[protein|search|abfA]'' [Pubmed|9084180]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9084180]
  • Regulation

  • repressed by glucose ([protein|search|CcpA]) [Pubmed|12949161]
  • induced by arabinose ([protein|search|AraR]) [Pubmed|10417639]
  • Regulatory mechanism

  • [protein|search|CcpA]: transcription repression [Pubmed|12949161]
  • [protein|search|AraR]: transcription repression [Pubmed|10417639]
  • References

  • 16585763,11418559,9084180,12949161,2500424,10417639,12949161,9084180,19727704