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pyrE [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]
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pyrE [Mon Aug 31 2015 13:54:13 GMT+0200 (CEST)]

orotate phosphoribosyltransferase
locus
BSU15560
pI
5.63
mw
23.00 kDa
function
pyrimidine biosynthesis
product
orotate phosphoribosyltransferase
essential
no
ec
2.4.2.10
synonyms
pyrX
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
    • syns
    pyrX

    [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides]

    • This gene is a member of the following [SW|regulons]

  • [SW|PyrR regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

    • Protein family

  • PyrE subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|3DEZ] (from ''Streptococcus mutans'', 59% identity, 74% similarity)

    • Expression and Regulation

    Operon

  • ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1709162]

    • Regulation

  • induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]

    • Regulatory mechanism

  • [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]

    • References

  • 8206849,1709162