part of the condensin complex, chromosomal origin condensation and segregation SMC protein
function
segregation of replication origins
product
chromosome condensation and segregation SMC protein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|DNA condensation/ segregation], [SW|essential genes]Gene
Coordinates on the chromosome (coding sequence)
1,666,560 -> 1,670,120
Phenotypes of a mutant
essential [Pubmed|12682299]terminal phenotype of a CRISPRi knockdown mutant is moderate lysis [Pubmed|27238023]''[protein|search|smc]'' mutants are not viable on complex medim that allow rapid growth, but they are viable under conditions of slow growth [Pubmed|24440399,24440393]''[protein|search|smc]'' lethality on complex medim can be suppressed by inactivation of ''[protein|search|ylbM]'' and ''[protein|search|tsaC]'' (constitutive [SW|stringent response]) [Pubmed|26539825]The protein
Protein family
SMC family (according to Swiss-Prot)Effectors of protein activity
ATP-induced DNA-binding results in a more open conformation of the [protein|search|Smc] dimer, and thus of the [SW|condensin] complex [Pubmed|25557547]Structure
[PDB|3ZGX] (complex between the head domain of [protein|search|Smc] (aa 1 - 219 and 983 - 1186) and the N-terminal winged-helix domain of [protein|search|ScpA]) [Pubmed|23353789][SW|Localization]
nucleoid (heterogeneous) [Pubmed|16479537]the [SW|condensin] ([protein|search|Smc])2-[protein|search|ScpA]-[protein|search|ScpB] complex forms two bipolar assemblies on the chromosome, one in each cell half, localization depends on [SW|Spo0J] [Pubmed|24440393,23475963][SW|Interactions]
part of the [SW|condensin] complex [Pubmed|24440399,24440393]forms dimers [Pubmed|22385855][protein|search|ScpA]-[protein|search|Smc] [Pubmed|12100548][protein|search|ScpB]-[protein|search|Smc], [Pubmed|22385855,12100548,12421306], this interaction takes place only in the presence of [protein|search|ScpA] [Pubmed|22385855][protein|search|Smc]-[protein|search|ParB] [Pubmed|19450516][protein|search|Smc] is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of [SW|interactions] [Pubmed|21630458]Expression and Regulation
Operon
''[protein|search|rnc]-[protein|search|smc]-[protein|search|ftsY]'' [Pubmed|11021934][SW|Sigma factor]
[protein|search|SigA] [Pubmed|11021934]Biological materials
Mutant
MGNA-B148 (smc::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1147 NBRP B. subtilis, Japan]1A822 ( ''smc''::pMUTIN ''trpC2'' Em), [Pubmed|12682299], available at [http://bgsc.org/getdetail.php?bgscid=1A822 the Bacillus Genetic Stock Center]BEC15940 (''smc''::''erm trpC2''), a CRISPRi knockdown mutant, [Pubmed|27238023], is available at the [http://bgsc.org Bacillus Genetic Stock Center]References
Reviews
19308706,22934648,22047950,22933559,24118085,25460803,26706151 Original publications
27238023,9791128,12100548,17416649,19450516,12421306,11395470,19450517,19450516,15009890,16479537,21630458,23353789,25071173,22385855,25951515,26253537,24440399,24440393,23475963,25557547,25664627,26295962,26539825,26725510,26904953,28154080 
