dapA

dihydrodipicolinate synthase

Locus: BSU_16770

Isoelectric point: 4.93

Molecular weight: 30.89 kDa

Protein length: 290 aa

Gene length: 873 bp

Function: biosynthesis of lysine and peptidoglycan

Product: dihydrodipicolinate synthase

Essential: yes

E.C.: 4.2.1.52

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of peptidoglycan
• Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of lysine/ threonine
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of peptidoglycan
• Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other
• Groups of genes → Essential genes

Gene

Coordinates: 1,748,368 1,749,240

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• L-aspartate 4-semialdehyde + pyruvate --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H⁺ + H₂O (according to UniProt)

Protein family

• DapA family (with YcbC, according to UniProt)

Structure

• 3CPR (from Corynebacterium glutamicum, 39% identity, 58% similarity) PubMed

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: asd-dapG-dapA
  Description: PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in SigK regulon
  • SigA: sigma factor, PubMed, in SigA regulon

• Genes: spoVFA-spoVFB-asd-dapG-dapA
  Description: PubMed

  Sigma factors

  • SigK: sigma factor, PubMed, in SigK regulon

  Regulation

  • expressed late during sporulation in the mother cell (SigK) PubMed

References

Reviews

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Original publications

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