niaP [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

nicotinate transporter

locus: BSU02950

pI: 9.00

mw: 43.00 kDa

function: uptake of niacin

product: nicotinate transporter

essential: no

synonyms: yceI

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.7|Transporter for cofactors]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|biosynthesis of cofactors], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|NadR regulon]

Gene

Coordinates on the chromosome (coding sequence): 317,725 -> 318,927

Phenotypes of a mutant

• more sensitive to nisin [Pubmed|23980836]

The protein

Protein family

• MFS transporter [Pubmed|18276644]

[SW|Domains]

• 10 membrane-spanning domains [Pubmed|18276644]

Structure

• [PDB|4J05] (from ''P. indica'', 24% identity) [Pubmed|23542591]

[SW|Localization]

• cell membrane [Pubmed|18763711]

Expression and Regulation

Operon

• ''[protein|search|niaP]'' [Pubmed|22383849]

Regulation

• repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|18276644]

Regulatory mechanism

• [protein|search|NadR]: transcription repression [Pubmed|18276644]

References

Reviews

• 21953179

Original publications

• 18763711,18276644,23980836,22383849,23542591