SubtiBank SubtiBank
dnaD
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dnaD

initiation of chromosome replication, part of the replisome
Locus
BSU_22350
Isoelectric point
7.17
Molecular weight
27.49 kDa
Protein length
232 aa Sequence Blast
Gene length
699 bp Sequence Blast
Product
initiation of chromosome replication
Essential
yes
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,345,433 → 2,346,131

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • DnaD-mediated untwisting of the DNA stimulates Nth endonuclease activity at AP sites PubMed
  • required for the assembly of the replicative helicase DnaC at the origin of replication PubMed
  • interaction with DnaA inhibits the ability of DnaA to bind cooperatively to DNA PubMed
  • Structure

  • 2C79 (N-terminal domain)
  • Localization

  • Membrane-proximal (Spotty) PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Regulation

  • constitutively expressed PubMed
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    Labs working on this gene/protein

  • Alan Grossman, MIT, Cambridge, MA, USA
  • References

    Reviews

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    Original publications

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