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resD
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resD

two-component response regulator (OmpR family), regulation of aerobic and anaerobic respiration, activates expression of target genes in response to oxygen limitation
Locus
BSU_23120
Isoelectric point
5.63
Molecular weight
27.34 kDa
Protein length
240 aa Sequence Blast
Gene length
723 bp Sequence Blast
Function
regulation of aerobic and anaerobic respiration
Product
two-component response regulator (OmpR family)
Essential
no
Synonyms
ypxD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Electron transport and ATP synthesis → Regulators of electron transport
  • Information processing → Regulation of gene expression → Transcription factors and their control → Two-component system response regulators
  • Groups of genes → Phosphoproteins → Phosphorylation on an Asp residue

    • Gene

    Coordinates
    2,417,181 2,417,903

    Phenotypes of a mutant

  • a resD point mutation has been isolated upon selction at low pressure PubMed

    • The protein

    Protein family

  • OmpR family of two-component response regulators

    • Domains

  • Response regulatory domain (aa 8-121) (according to UniProt)

    • Modification

  • phosphorylated by ResE on an Asp residue

    • Effectors of protein activity

  • phosphorylation likely affects DNA-binding activity

    • Structure

  • 2OQR (RegX3 from Mycobacterium tuberculosis, 37% identity) PubMed

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Additional information

  • ResD may interact with RNA polymerase PubMed
  • information on binding sites can be found in the PRODORIC2 database

    • Expression and Regulation

    Operons

    Genes
    rluB-resA-resB-resC-resD-resE
    Description
    PubMed
    view in new tab

    Genes
    resA-resB-resC-resD-resE
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • ResD: activation, PubMed, in ResD regulon
  • PhoP: activation, PubMed, in PhoP regulon
  • CcpA: repression, PubMed, in CcpA regulon

    • Regulation

  • expressed under anaerobic conditions (ResD) PubMed
    • view in new tab

    Genes
    resD-resE
    Description
    PubMed

    Regulation

  • expressed under anaerobic conditions (ResD) PubMed
    • view in new tab

    Biological materials

    Mutant

  • BKE23120 (resD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTTTCCCCCTGCTTTC, downstream forward: _UP4_TATAAATTTGAGGTCGGCGC
  • BKK23120 (resD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTTTTCCCCCTGCTTTC, downstream forward: _UP4_TATAAATTTGAGGTCGGCGC

    • Labs working on this gene/protein

  • Marion Hulett, University of Illinois at Chicago, USA Homepage

    • References

    Reviews

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    Original publications

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