SubtiBank SubtiBank
purR
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purR

transcription repressor of the pur operon
Locus
BSU_00470
Isoelectric point
5.77
Molecular weight
31.08 kDa
Protein length
285 aa Sequence Blast
Gene length
858 bp Sequence Blast
Function
regulation of purine biosynthesis
Product
transcription repressor of the pur operon
Essential
no
Synonyms
yabI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of purine nucleotides
  • Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

    • Gene

    Coordinates
    54,441 55,298

    The protein

    Protein family

  • Purine/pyrimidine phosphoribosyltransferase family (according to UniProt)

    • Effectors of protein activity

  • PRPP acts as inducer, binding results in release of PurR from the operator PubMed

    • Structure

  • 1O57, 1O57 NCBI PubMed

    • Additional information

  • requires YabJ for in vivo activity
  • information on binding sites can be found in the PRODORIC2 database

    • Expression and Regulation

    Operons

    Genes
    ispE-purR-yabJ
    Description
    PubMed

    Regulatory mechanism

  • PurR: repression, PubMed, in PurR regulon

    • Regulation

  • negative autoregulation PubMed
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    Biological materials

    Mutant

  • BKE00470 (purR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAACTCACCCCCAAAAT, downstream forward: _UP4_TTAAAGAATGGAGAGACAGA
  • BKK00470 (purR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGAACTCACCCCCAAAAT, downstream forward: _UP4_TTAAAGAATGGAGAGACAGA

    • References

    Reviews

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    Original publications

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