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polC
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polC

DNA polymerase III, leading strand polymerase (alpha subunit), part of the replisome
Locus
BSU_16580
Isoelectric point
5.14
Molecular weight
162.42 kDa
Protein length
1437 aa Sequence Blast
Gene length
4311 bp Sequence Blast
Function
DNA replication
Product
DNA polymerase III (alpha subunit)
Essential
yes
E.C.
2.7.7.7
Synonyms
mutI,dnaF,dnaP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → Genetics → DNA replication
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    1,727,133 → 1,731,446

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) --> diphosphate + DNA(n+1) (according to UniProt)
  • required for bacteriophage SPP1 replication PubMed

    • Protein family

  • DNA polymerase type-C family (with YorL and DnaE, according to UniProt)

    • Domains

  • Exonuclease domain (aa 421-578) (according to UniProt)

    • Structure

  • 3F2B (from Geobacillus kaustophilus, 71% identity) PubMed

    • Localization

  • forms foci PubMed
  • about three molecules of PolC at each replication fork PubMed

    • Expression and Regulation

    Operons

    Genes
    ispC-rasP-proS-polC
    Description
    PubMed
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    Genes
    uppS-cdsA-ispC-rasP-proS-polC
    Description
    PubMed
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    Additional information

  • about 60 molecules per cell PubMed

    • References

    Reviews

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    Original publications

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