SubtiBank SubtiBank
hemH
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hemH

coproporphyrin ferrochelatase
Locus
BSU_10130
Isoelectric point
4.62
Molecular weight
35.19 kDa
Protein length
310 aa Sequence Blast
Gene length
933 bp Sequence Blast
Function
biosynthesis of heme
Product
coproporphyrin ferrochelatase
Essential
no
E.C.
4.99.1.1
Synonyms
hemF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Biosynthesis of cofactors → Biosynthesis of heme/ siroheme

    • Gene

    Coordinates
    1,087,250 → 1,088,182

    The protein

    Catalyzed reaction/ biological activity

  • coproporphyrin --> coproheme PubMed
  • 2 H+ + heme b --> Fe2+ + protoporphyrin IX (according to UniProt)

    • Protein family

  • ferrochelatase family (with YlnF, according to UniProt)

    • Structure

  • 2HK6 (complex with iron) PubMed
  • 1AK1 PubMed

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    hemE-hemH-hemY
    Description
    PubMed
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    Biological materials

    Mutant

  • BKE10130 (ΔhemH::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG
  • BKK10130 (ΔhemH::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CACTGTTTACACCCTCTTTA, downstream forward: _UP4_GGACGTTAAAGAAGGCGATG

    • References

    Reviews

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    Original Publications

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