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gamR

transcriptional repressor (GntR family) of the gamA-gamP operon

Locus

BSU_02370

Isoelectric point

5.56

Molecular weight

26.45 kDa

Protein length

235 aa Sequence Blast

Gene length

708 bp Sequence Blast

Function

regulation of glucosamine utilization

Product

transcriptional regulator (GntR family)

Essential

Synonyms

ybgA

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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Categories containing this gene/protein

Cellular processes → Cell envelope and cell division → Cell wall degradation/ turnover → Utilization of cell wall components

Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of amino sugars

Metabolism → Amino acid/ nitrogen metabolism → Utilization of nitrogen sources other than amino acids → Utilization of amino sugars

Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

Gene

Coordinates

257,791 → 258,498

The protein

Protein family

GntR family of transcription factors

Domains

HTH gntR-type domain (aa 2-70) (according to UniProt)

Effectors of protein activity

glucosamine-6-phosphate acts as molecular inducer that prevents GamR from binding to its operator sites in the promoter regions of the gamA-gamP and gamR-ybgB operons PubMed

Structure

2WV0 (NagR, 34% identity) PubMed

Expression and Regulation

Operons

Genes

gamR-ybgB

Description

PubMed

Sigma factors

SigA: sigma factor, PubMed, in SigA regulon

Regulatory mechanism

GamR: repression, PubMed, in GamR regulon

Regulation

induced by glucosamine (gamR) PubMed

induced by glucosamine (GamR) PubMed

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Biological materials

Mutant

BKE02370 (ΔgamR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTCATTCTCCCCATTCT, downstream forward: _UP4_TAAAGCAATGTGTTTTAAGA

BKK02370 (ΔgamR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTCATTCTCCCCATTCT, downstream forward: _UP4_TAAAGCAATGTGTTTTAAGA

References

Reviews

Original publications