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fur

transcription regulator of iron homoeostasis, sensor of Fe sufficiency

Locus

BSU_23520

Isoelectric point

5.37

Molecular weight

17.26 kDa

Protein length

149 aa Sequence Blast

Gene length

450 bp Sequence Blast

Function

regulation of iron homoeostasis

Product

transcriptional repressor Fur family

Essential

Synonyms

yqkL

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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Categories containing this gene/protein

Cellular processes → Homeostasis → Acquisition of iron → Acquisition of iron / Other

Metabolism → Additional metabolic pathways → Iron metabolism → Acquisition of iron / Other

Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

Gene

Coordinates

2,449,841 → 2,450,290

Phenotypes of a mutant

no growth with glucose and ammonium as single sources of carbon and nitrogen, respectively (due to FsrA-mediated repression of the gltA-gltB operon) PubMed

poor growth on lactate as single carbon source (due to overexpression of FsrA-mediated repression of the lutA-lutB-lutC operon, can be suppressed by inactivation of fsrA or fbpB) PubMed

transcription profile of a fur mutant strain: GEO PubMed

The protein

Protein family

Fur family (according to UniProt)

Paralogous protein(s)

PerR, Zur

Cofactors

Fe²⁺ PubMed

Effectors of protein activity

DNA binding activity (repression) is triggered by binding of Fe²⁺ PubMed

Structure

4ETS (from Campylobacter jejuni, 33% identity) PubMed