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  • Description: β-hydroxyacyl-(acyl carrier protein) dehydratase

Gene name ywpB
Essential no
Product β-hydroxyacyl-ACP dehydratase
Function fatty acid biosynthesis
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 14 kDa, 9.36
Gene length, protein length 396 bp, 132 aa
Immediate neighbours mscL, rapD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YwpB context.gif
This image was kindly provided by SubtiList

The gene

Basic information

  • Locus tag: BSU36370

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: FabZ subfamily (according to Swiss-Prot)
  • Paralogous protein(s): YcsD

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 3D6X (from Campylobacter jejuni, 45% identity, 67% similarity) PubMed
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Andrew S Kirkpatrick, Takeshi Yokoyama, Kyoung-Jae Choi, Hye-Jeong Yeo
Campylobacter jejuni fatty acid synthase II: structural and functional analysis of beta-hydroxyacyl-ACP dehydratase (FabZ).
Biochem Biophys Res Commun: 2009, 380(2);407-12
[PubMed:19280690] [WorldCat.org] [DOI] (I p)

Yasutaro Fujita, Hiroshi Matsuoka, Kazutake Hirooka
Regulation of fatty acid metabolism in bacteria.
Mol Microbiol: 2007, 66(4);829-39
[PubMed:17919287] [WorldCat.org] [DOI] (P p)