Difference between revisions of "YlmE"

From SubtiWiki
Jump to: navigation, search
Line 52: Line 52:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15380&redirect=T BSU15380]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ylmDEFGH.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ylmDEFGH.html]
Line 89: Line 90:
  
 
=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU15380&redirect=T BSU15380]
  
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=1W8G 1W8G] (the structure of YggS from ''E. coli'' 33% identity, 61% similarity)
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=1W8G 1W8G] (the structure of YggS from ''E. coli'' 33% identity, 61% similarity)

Revision as of 13:40, 2 April 2014

  • Description: enzyme involved in controlling the availability of coenzyme A

Gene name ylmE
Synonyms
Essential no
Product unknown
Function control of the CoA pool
Gene expression levels in SubtiExpress: ylmE
MW, pI 25 kDa, 5.546
Gene length, protein length 690 bp, 230 aa
Immediate neighbours ylmD, sepF
Sequences Protein DNA DNA_with_flanks
Genetic context
YlmE context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YlmE expression.png















Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU15380

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • while the protein was described as an amino acid racemase important for biofilm formation PubMed, no racemase activity was detected in in vitro assays with a functionally active protein PubMed
  • Protein family: UPF0001 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 1W8G (the structure of YggS from E. coli 33% identity, 61% similarity)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Tomokazu Ito, Jumpei Iimori, Sayuri Takayama, Akihito Moriyama, Ayako Yamauchi, Hisashi Hemmi, Tohru Yoshimura
Conserved pyridoxal protein that regulates Ile and Val metabolism.
J Bacteriol: 2013, 195(24);5439-49
[PubMed:24097949] [WorldCat.org] [DOI] (I p)

Leendert W Hamoen, Jean-Christophe Meile, Wouter de Jong, Philippe Noirot, Jeff Errington
SepF, a novel FtsZ-interacting protein required for a late step in cell division.
Mol Microbiol: 2006, 59(3);989-99
[PubMed:16420366] [WorldCat.org] [DOI] (P p)

Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol Microbiol: 2003, 50(5);1683-701
[PubMed:14651647] [WorldCat.org] [DOI] (P p)