From SubtiWiki
Revision as of 14:22, 2 April 2014 by (talk)
Jump to: navigation, search
  • Description: production of squalene-derived polyisoprenoids

Gene name yisP
Synonyms yucD
Essential no
Product squalene synthase
Function control of KinC activity
Gene expression levels in SubtiExpress: yisP
MW, pI 31 kDa, 7.258
Gene length, protein length 822 bp, 274 aa
Immediate neighbours yizA, yisQ
Sequences Protein DNA DNA_with_flanks
Genetic context
YisP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YisP expression.png

Categories containing this gene/protein

biosynthesis of lipids, phosphorelay, biofilm formation

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU10810

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

The gene is annotated in KEGG as an ortholog of phytoene synthase EC No EC annotation is available in Swiss-Prot/MetaCSwiss-Prot/MetaCyc.literature/experimental evidence supporting the annotation is available. PubMed

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Juri Niño Bach, Marc Bramkamp
Flotillins functionally organize the bacterial membrane.
Mol Microbiol: 2013, 88(6);1205-17
[PubMed:23651456] [WorldCat.org] [DOI] (I p)

Yumei Hu, Shiru Jia, Feifei Ren, Chun Hsiang Huang, Tzu Ping Ko, Douglas A Mitchell, Rey Ting Guo, Yingying Zheng
Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168.
Acta Crystallogr Sect F Struct Biol Cryst Commun: 2013, 69(Pt 1);77-9
[PubMed:23295493] [WorldCat.org] [DOI] (I p)

Daniel López, Roberto Kolter
Functional microdomains in bacterial membranes.
Genes Dev: 2010, 24(17);1893-902
[PubMed:20713508] [WorldCat.org] [DOI] (I p)

Tzu-Lin Hsiao, Olga Revelles, Lifeng Chen, Uwe Sauer, Dennis Vitkup
Automatic policing of biochemical annotations using genomic correlations.
Nat Chem Biol: 2010, 6(1);34-40
[PubMed:19935659] [WorldCat.org] [DOI] (I p)